Ulus Travma Acil Cerrahi Derg. 2022; 28(5): 607-614 | DOI: 10.14744/tjtes.2022.30434

Komplike akut apandisiti ayýrt etmede nötrofil-trombosit oranýnýn, immature granülosit- lenfosit oranýnýn, eritrosit daðýlýmý geniþliði-lenfosit oranýnýn deðeri

Mehmet Kubat¹, Serkan Þengül^2
1Alanya Eðitim ve Araþtýrma Hastanesi, Genel Cerrahi Kliniði, Antalya
²Alanya Alaaddin Keykubat Üniversitesi Týp Fakültesi, Genel Cerrahi Anabilim Dalý, Antalya

AMAÇ: Komplike olmayan akut apandisit olgularýnda týbbi tedavi baþarýsýnýn olabileceðinin anlaþýlmasý üzerine, komplike akut apandisit olgularýnýn baþarýlý bir þekilde ayýrt edilmesi gerekliliði ortaya çýkmýþtýr. Çalýþmamýzda, nötrofil/trombosit oraný, immatür granülosit/lenfosit oraný, eritrosit daðýlýmý geniþliði/lenfosit oraný parametrelerinin komplike-komplike olmayan akut apandisit olgularýnýn ayrýmýndaki kullanýlabilirliði irdelemektedir. GEREÇ VE YÖNTEM: Ocak 2019/Aralýk 2020 tarihleri arasýnda apendektomi yapýlan hastalar geriye dönük olarak deðerlendirildi. Patolojik ve klinik bulgulara göre negatif apendektomi, komplike akut apandisit ve komplike olmayan akut apandisit gruplarýna ayrýldý. Laboratuvar parametreleri ve bu parametrelerden elde edilen oranlar gruplar arasýnda deðerlendirildi.
BULGULAR: Çalýþmaya 348 hasta alýndý. Hastalarýn %11.2’sinin komplike akut apandisit, %81.6’sýnýn komplike olmayan akut apandisit ve %7.2’si-nin negatif apendektomi olduðu görüldü. Komplike-komplike olmayan akut apandisit ayrýmýnda; nötrofil/lenfosit oraný (AUC=0.742), trombosit/lenfosit oraný (AUC=0.707), immatür granülosit/lenfosit oraný (AUC=0.782), monosit/lenfosit oraný (AUC=0.720) ve eritrosit daðýlýmý geniþliði/lenfosit oraný (AUC=0.711) anlamlý bulundu. Nötrofil/trombosit oraný (AUC=0.789) pozitif apendektomi-negatif apendektomi ayrýmýnda anlamlý bulundu.
TARTIÞMA: Daha önce akut apandisit tanýlý olgularda çalýþýlmamýþ olan immatür granülosit/lenfosit oraný, nötrofil/trombosit oraný, monosit/lenfosit oraný, eritrosit daðýlýmý geniþliði/lenfosit oraný parametreleri; komplike akut apandisit-komplike olmayan akut apandisit gruplarý ayrýmýnda kullanýlabilir olduklarý sonucuna varýldý.

Anahtar Kelimeler: Akut apandisit, eritrosit daðýlým geniþliði/lenfosit oraný; immatür granülosit/lenfosit oraný; komplike apandisit; monosit/lenfosit oraný; nötrofil/trombosit oraný.

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Value of neutrophil-to-platelet ratio, immature granulocyte-to-lymphocyte ratio, red blood cell distribution width-to-lymphocyte ratio in differentiating complicated acute appendicitis

Mehmet Kubat¹, Serkan Þengül^2
1Department of General Surgery, Alanya Training and Research Hospital, Antalya-Turkey
²Department of General Surgery, Alanya Alaaddin Keykubat University Faculty of Medicine, Antalya-Turkey

BACKGROUND: The discovery that medical treatment could be successful in cases with uncomplicated acute appendicitis (UCAA) has revealed the need for successfully differentiating cases with complicated acute appendicitis (CAA). The present study exam-ined the usability of neutrophil-to-platelet ratio (NPR), immature granulocyte-to-lymphocyte ratio, and red blood cell distribution width-to-lymphocyte ratio (RDWLR) in the CAA/UCAA differentiation.
METHODS: A retrospective evaluation was made of patients undergoing appendectomy between January 2019 and December 2020. According to pathological and clinical findings, the patients were divided into negative appendectomy, CAA and UCAA groups. Labo-ratory parameters and associated ratios were evaluated by comparing the groups.
RESULTS: The study included 348 patients. Of the patients, 11.2% had CAA, 81.6% had UCAA, and 7.2% had negative appendec-tomy. The neutrophil-to-lymphocyte ratio (AUC=0.742), platelet-to-lymphocyte ratio (AUC=0.707), immature granulocyte-to-lym-phocyte ratio (AUC=0.782), monocyte-to-lymphocyte ratio (AUC=0.720), and RDWLR (AUC=0.711) were found significant in the differentiation between complicated and uncomplicated AA. The NPR (AUC=0.789) was found to be significant in the differentiation between positive and negative appendectomy.
CONCLUSION: It was concluded that the immature granulocyte-to-lymphocyte ratio, NPR, monocyte-to-lymphocyte, and RD-WLR, which have not been previously studied in patients with acute appendicitis (AA), could be used to differentiate between com-plicated and uncomplicated AA groups.

Keywords: Acute appendicitis, complicated appendicitis; Immature granulocyte-to-lymphocyte ratio; monocyte-to-lymphocyte ratio; neutrophil-to-platelet ratio; red blood cell distribution width-to-lymphocyte ratio.

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