Hızlı Arama
TAVŞANLARDA PERİKONDRİUM GREFTLERİNDEN YENİ KIKIRDAK OLUŞUMUNA HETEROLOG KOLLAJENİN ETKİSİ
Serhat Özbek1, Cenk Şen2, Zeynep Kahveci2, Mesut Özcan21Uludağ Üniversitesi Tıp Fakültesi Plastik ve Rekonstrüktif Cerrahi Anabilim Dalı, Bursa, Turkey, [email protected]2Uludağ Üniversitesi Tıp Fakültesi Plastik ve Rekonstrüktif Cerrahi Anabilim Dalı, Bursa, Turkey
3Uludağ Üniversitesi Tıp Fakültesi Plastik ve Rekonstrüktif Cerrahi Anabilim Dalı, Bursa, Turkey
4Uludağ Üniversitesi Tıp Fakültesi Plastik ve Rekonstrüktif Cerrahi Anabilim Dalı, Bursa, Turkey
THE EFFECT OF HETEROLOGOUS COLLAGEN IN NEOCHONDROGENESIS FROM FREE PERICHONDRIAL GRAFTS, IN RABBITS: AN EXPERIMENTAL STUDY
Serhat Özbek1, Cenk Şen2, Zeynep Kahveci2, Mesut Özcan21Uludağ Üniversitesi Tıp Fakültesi Plastik ve Rekonstrüktif Cerrahi Anabilim Dalı, Bursa, Turkey, [email protected]2Uludağ Üniversitesi Tıp Fakültesi Plastik ve Rekonstrüktif Cerrahi Anabilim Dalı, Bursa, Turkey
3Uludağ Üniversitesi Tıp Fakültesi Plastik ve Rekonstrüktif Cerrahi Anabilim Dalı, Bursa, Turkey
4Uludağ Üniversitesi Tıp Fakültesi Plastik ve Rekonstrüktif Cerrahi Anabilim Dalı, Bursa, Turkey
Background: After chondrogenic potential of perichondrium was recognized, perichondrial grafts have been used in reconstruction of cartilage defects. Enhancing neochondrogenesis has many advantages, in this regard. This experimental study was done in the aim of identifying whether the heterologous collagen has an accelerating effect on neochondrogenesis from perichondrial grafts or not.
Methods: We placed perichondrial grafts, onto the dorsal muscles of twelve white New-Zealand rabbits, on both sides. On one side, heterologous collagen sponge was inserted between the graft and the muscle, the other side served as a control.
Results: As a result of histological assessment on days 45, 120 and 180, we obtained that heterologous collagen enhanced the neochondrogenesis.
Conclusion: We believe that, if any cartilage defect would be reconstructed with a Perichondrial graft, additional use of heterologous collagen will be helpful.
Makale Dili: Türkçe