HEMORAJ�K �OKTA OKS�JEN SERBEST RAD�KALLER� �ZER�NE H�PERTON�K SAL�N, HAES VE D�MET�LS�LFOKS�T��N ETK�LER�

Karag�zo�lu, Emrah; G�l, Mehmet; Karabulut, Kaan; Bay�r, Ay�eg�l; Kafal�, M. Ertu�rul; Ak, Ahmet; �ahin, Mustafa

Cilt : 9 Say� : 3 Y�l : 2024

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HEMORAJ�K �OKTA OKS�JEN SERBEST RAD�KALLER� �ZER�NE H�PERTON�K SAL�N, HAES VE D�MET�LS�LFOKS�T��N ETK�LER� [Ulus Travma Acil Cerrahi Derg]

Ulus Travma Acil Cerrahi Derg. 2003; 9(3): 154-159

HEMORAJ�K �OKTA OKS�JEN SERBEST RAD�KALLER� �ZER�NE H�PERTON�K SAL�N, HAES VE D�MET�LS�LFOKS�T��N ETK�LER�

Emrah Karag�zo�lu¹, Mehmet G�l², Kaan Karabulut³, Ay�eg�l Bay�r², M. Ertu�rul Kafal�², Ahmet Ak², Mustafa �ahin⁴
¹Meram Medical Faculty Of Sel�uk University Biochemistry Department, Konya, Turkey
²Meram Medical Faculty Of Sel�uk University Emergency Department, Konya, Turkey
³Meram Medical Faculty Of Sel�uk University Anatomy Department, Konya, Turkey
⁴Meram Medical Faculty Of Sel�uk University General Surgery Department, Konya, Turkey

EFFECTS OF HYPERTONIC SALINE, HAES AND DIMETHYLSULPHOXIDE ON FREE OXYGEN RADICALS IN HAEMORRHAGIC SHOCK OXYGEN RADICALS IN HAEMORRHAGIC SHOCK

Emrah Karag�zo�lu¹, Mehmet G�l², Kaan Karabulut³, Ay�eg�l Bay�r², M. Ertu�rul Kafal�², Ahmet Ak², Mustafa �ahin⁴
¹Meram Medical Faculty of Sel�uk University Biochemistry Department, Konya, Turkey
²Meram Medical Faculty of Sel�uk University Emergency Department, Konya, Turkey
³Meram Medical Faculty of Sel�uk University Anatomy Department, Konya, Turkey
⁴Meram Medical Faculty of Sel�uk University General Surgery Department, Konya, Turkey

Background: The aim of this study was to investigate the effects of antioxidant and resuscitation fluids which were used during haemorrhagic shock on tissue ischemia.
Methods: Forty New Zealand type rabbits were divided into four groups as C (control), I (hypertonic saline), H (HAES) and D (Dymethylsulphdxide-DMSO). Haemorrhagic shock was induced by bleeding from carotid artery. Thirty minutes after shock, Group C was not resuscitated while Group I was resuscitated with Hypertonic saline 7.2, Group H with 10 % HAES and Group D with HAES 10 % and DMSO. Thiobarbituric acid reactive substances (TBARS) and lactate levels in blood, liver and small bowel samples were measured.
Results: There were no significant differences among the groups tissue and plasma TBARS and lactate levels.
Conclusion: Resuscitation fluids and addition of antioxidants to the resuscitation fluids do not have any superiorities over each other to prevent tissue ischemic insult in haemorrhagic shock.

Keywords: Haemorrhagic shock, hypertonic saline, oxygen free radicals, imethylsulphoxide, antioxidants

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