Ulus Travma Acil Cerrahi Derg. 2006; 12(3): 189-194

Hipotansif sýçan modelinde düþük doz dopamin infüzyonunun böbrek koruyucu etkisi: Deneysel çalýþma

Hatice Kaya¹, Hale Tufan², Mehmet Özdoðan³, Gülnaz Arslan^1
1Baþkent Üniversitesi Týp Fakültesi, Anesteziyoloji Ve Reanimasyon Anabilim Dalý, Ankara
²Baþkent Üniversitesi Týp Fakültesi, Farmakoloji Anabilim Dalý, Ankara
³Hacettepe Üniversitesi Týp Fakültesi, Genel Cerrahi Anabilim Dalý, Ankara

AMAÇ: Bu çalýþmada hipotansif sýçan modelinde düþük doz dopamin infüzyonunun böbrek koruyucu etkisi araþtýrýldý.
GEREÇ-YÖNTEM: Çalýþmada kontrol, hipotansiyon, dopamin ve dopamin+hipotansiyon gruplarýna ayrýlan Wistar cinsi 40 sýçan kullanýldý. Hipotansiyon yaratmak için sodium nitroprussid infüzyonu kullanýldý ve iki saatlik çalýþma süresince kan ve idrar örnekleri toplandý.
BULGULAR: Hipotansiyon grubunda kan üre nitrojen düzeyinin çalýþmanýn birinci saatinde anlamlý derecede yükseldiði, fakat çalýþma süresinin sonunda bu farkýn kaybolduðu gözlendi. Dopamin infüzyonunun kreatinin ve potasyum klirensine etkisi gözlenmedi. Sadece dopamin verilen sýçanlarda natriürez gözlenmezken, dopamin verilen hipotansif sýçanlarda idrar sodyum atýlýmýnýn anlamlý derecede arttýðý saptandý.
SONUÇ: Düþük doz dopamin infüzyonunun farmakolojik olarak oluþturulan hipotansiyonun erken safhasýndaki kan üre nitrojen yükselmesine karþý engelleyici etki gösterdiði saptandý.

Anahtar Kelimeler: Kan üre nitrojen, kreatin; düþük doz dopamin; reseptör, dopamin; böbrek fonksiyonu.

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The protective effect of low-dose dopamine on renal functions in hypotensive rats: an experimental study

Hatice Kaya¹, Hale Tufan², Mehmet Özdoðan³, Gülnaz Arslan^1
1Departments Of Anesthesiology And Reanimation, Medicine Faculty Of Baþkent University, Ankara, Turkey
²Departments Of Pharmacology, Medicine Faculty Of Baþkent University, Ankara, Turkey
³Department Of General Surgery, Medicine Faculty Of Hacettepe University, Ankara, Turkey

BACKGROUND: The aim of this study was to investigate the effect of low-dose dopamine on markers of the renal functions in a rat model of hypotension.
METHODS: Forty Wistar rats were divided into control, hypotension, dopamine, and hypotension+dopamine groups. Hypotension was achieved by sodium-nitroprusside infusion. Samples were drawn for analysis during the two-hour study period.
RESULTS: Blood urea nitrogen levels were significantly increased in hypotension group during the early phase but this difference disappeared at the end of the second hour. Dopamine infusion had no effect on creatinine and potassium clearance. Despite the significance of improved sodium clearance in the hypotensive rats treated with dopamine, natriuresis did not occurred in the dopamine-only group.
CONCLUSION: It can be stated that low dose dopamine infusion at a rate of 0.5 µg kg-1 min-1 has a short-term preventive action against the increase of blood urea nitrogen during the early phase of pharmacologically induced hypotension.

Keywords: Blood urea nitrogen, creatinine; low-dose dopamine; receptors, dopamine; renal function.

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