�NCE BARSAKLARDA MEZENTER ARTER �SKEM�S�NE BA�LI �SKEM� REPERF�ZYON HASARI �ZER�NE PROSTAGLAND�N E2'N�N ETK�S�

Topalo�lu, �mit; G�ran, Mithat; Odaba��, Mehmet; Karada�, Ne�e; �enel, G�ksel; Kabasakal, Levent; �nalm��er, Sel�uk

Cilt : 3 Say� : 4 Y�l : 2024

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�NCE BARSAKLARDA MEZENTER ARTER �SKEM�S�NE BA�LI �SKEM� REPERF�ZYON HASARI �ZER�NE PROSTAGLAND�N E2'N�N ETK�S� [Ulus Travma Acil Cerrahi Derg]

Ulus Travma Acil Cerrahi Derg. 1997; 3(4): 258-264

�NCE BARSAKLARDA MEZENTER ARTER �SKEM�S�NE BA�LI �SKEM� REPERF�ZYON HASARI �ZER�NE PROSTAGLAND�N E2'N�N ETK�S�

�mit Topalo�lu¹, Mithat G�ran¹, Mehmet Odaba��¹, Ne�e Karada�¹, G�ksel �enel¹, Levent Kabasakal¹, Sel�uk �nalm��er¹
Haydarpa�a Numune Hastanesi 4. Cerrahi Klini�i

�nce barsaklarda mezenter arter iskemisine ba�l� iskemi-reperf�zyon hasar�n� ve PGE2'nin etkisini g�zlemek i�in 40 s��anda eksperimental �al��ma yap�ld�. Sham, ligasyon, deney ve ligasyon + prostaglandin E2 guruplar� yap�ld�. Superior mezenterik arter aortadan ��k�� yerinden atravmatik mikrovask�ler klemplerle tutularak bir saatlik iskemi ve iki saatlik reperf�zyon sa�land�. 1 ve 3. saatlerde CPK, LDH, AST ve ALT analizi i�in kan �rnekleri, malondialdehit ve red�kte glutatyon saptanmas� ve histopatolojik inceleme amac�yla intestinal doku �rnekleri al�nd�. CPK, LDH, AST ve ALT de�erleri SMA ligasyonunu takiben y�kseldi ve PGE2 verilen gurupta anlaml� d��me saptand�. Glutatyon seviyesi ligasyon gurubunda olduk�a d��k, PGE2 verilen gurupta lipit peroksidasyonun �r�n� olan malondialdehit anlaml� olarak d��k saptand�. Sonu� olarak histopatolojik bulgular�n biyokimyasal bulgularla paralellik g�sterdi�i ve PGE2'nin barsaklardaki, iskemik hasar� anlaml� olarak azaltt��, daha da �nemlisi iskemik hasar�n irreversible safhaya gelmesini �nledi�i g�zlendi.

Anahtar Kelimeler: �NTEST�NAL �SKEM�, REPERF�ZYON HASARI, PROSTAGLAND�N E2

THE EFFECTS OF PROSTAGLANDIN E2 ON ISCHEMIA-REPERFUSION DAMAGE, RESULTING FROM MESENTER ARTERIAL ISCHEMIA IN SMALL INTESTINES

�mit Topalo�lu¹, Mithat G�ran¹, Mehmet Odaba��¹, Ne�e Karada�¹, G�ksel �enel¹, Levent Kabasakal¹, Sel�uk �nalm��er¹
Haydarpa�a Numune Hastanesi 4. Cerrahi Klini�i

To observed the ischemia reperfusion damage and the effect of PGE2 resulting from mezenter arterial ischemia on 40 rats an experimental study is carried out. One-hour ischemia and two hour reperfusion model is applied by clemping the superior mesenteric artery at bifurcation site from aorta abdominal with atravmatic microvasculer in sham, ligation, experiment and ligation + PGE2 (n=10) groups. The blood samples were taken for alanine transaminase (ALT), aspartate transaminase (AST), lactic dehydrogenase (LDH), creatinin phosphokinase (CPK) analysis at 1st and 3rd hours. Intestinal tissue samples were removed for malonyldialdehyde and reduced glutathione determinations and histopathologic examination. CPK, LDH, AST and ALT values increased after the SMA ligation and there was a meaningful decrease in the group that was given PGE2. Glutation levels were rather low in the ligation group and malonyldialdehyde, the product of lipid peroxidatiton decreased in the PGE2 group. Finally; it is observed that histopathologic findings were in concordance with biochemical results and it is also found out that PGE2 lessens the ischemic damage in small intestines, furthermore, PGE2 enhances the ischemic damage to reach irreversible phase.

Keywords: INTESTINAL ISCHEMIA, REPERFUSION DAMAGE, PROSTAGLANDIN E2

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