Akut kolesistitte pentraxin 3 d�zeyinin prognostik �nemi

Aksungur, Nurhak; Ozogul, Bunyami; Ozturk, Nurunnisa; Arslan, Sukru; Karadeniz, Erdem; Korkut, Ercan; G�l, Mehmet Ali; K�saoglu, Abdullah; Atamanalp, Sabri Selcuk

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Akut kolesistitte pentraxin 3 d�zeyinin prognostik �nemi [Ulus Travma Acil Cerrahi Derg]

Ulus Travma Acil Cerrahi Derg. 2015; 21(5): 380-384 | DOI: 10.5505/tjtes.2015.38839

Akut kolesistitte pentraxin 3 d�zeyinin prognostik �nemi

Nurhak Aksungur¹, Bunyami Ozogul¹, Nurunnisa Ozturk², Sukru Arslan¹, Erdem Karadeniz¹, Ercan Korkut¹, Mehmet Ali G�l², Abdullah K�saoglu¹, Sabri Selcuk Atamanalp¹
¹Atat�rk �niversitesi T�p Fak�ltesi, Genel Cerrahi Ana Bilim Dal�, Erzurum
²Atat�rk �niversitesi T�p Fak�ltesi, Biyokimya Ana Bilim Dal�, Erzurum

AMA�: Safra ta�� hastal�� geli�mi� �lkelerde s�k g�r�len bir sorundur. Eri�kinlerin en az %10�unda safra ta�� vard�r. Safra ta�� olan insanlar�n %40�60�� semptomsuz klinik seyir g�sterirken, semptomlu kolelitiazisi olan olgular�n �o�unda da semptomsuz bir d�nem bulunur. Semptomlu safra ta�lar�n�n %20�si akut kolesistit tablosu ile acil servislere ba�vurur. Bu �al��mada, akut kolesistitli olgularda, pentraksin 3 (PTX3) d�zeylerin komplikasyonlar ve prognoz �zerindeki tan�sal de�erini belirlemeyi ve akut kolesistit olgular�nda morbidite ve mortalite oranlar�n� azaltmay� ama�lad�k.
GERE� VE Y�NTEM: Bu �al��ma Atat�rk �niversitesi T�p Fak�ltesi Genel Cerrahi Servisi�nde Eyl�l 2012�Ocak 2014 tarihleri aras�nda akut ta�l� kolesistit tan�s� konulup ameliyat edilen hastalar �zerinde yap�ld�. �al��maya ya�lar� 18�den b�y�k, klinik ve radyolojik olarak akut ta�l� kolesistit tan�s� konmu� 45 hasta (Grup I) ve 18 ya� �st� 45 sa�l�kl� (Grup II) ki�i al�nd�. Olgular randomize olarak se�ildi.
BULGULAR: �al��mam�zda plazma PTX3 d�zeyinin hasta grubunda ve morbidite geli�en hastalarda y�ksek olmakla birlikte istatisitiksel olarak anlaml� de�ildi. Pentraksin 3 de�erlerinin ileri ya� hastalarda anlaml� olarak artt�� saptand� (p<0.05). Ayr�ca hastanede yat�� s�reli kar��la�t�r�ld��nda PTX3��n hastanede daha uzun s�re yatan hastalarda daha y�ksek oldu�u belirlendi (p<0.05).
TARTI�MA: Pentraksin 3 d�zeyleri akut kolesistitli hastalarda de�erlendirilen t�m parametrelerde y�ksek bulundu. Bu y�zden PTX3 d�zeyleri akut kolesistitte tan� ve prognoz tahmininde de�erli bir g�sterge olabilir.

Anahtar Kelimeler: Akut kolesistit, morbidite; mortalite; pentraxin 3.

Prognostic importance of pentraxin 3 levels in acute cholesistitis

Nurhak Aksungur¹, Bunyami Ozogul¹, Nurunnisa Ozturk², Sukru Arslan¹, Erdem Karadeniz¹, Ercan Korkut¹, Mehmet Ali G�l², Abdullah K�saoglu¹, Sabri Selcuk Atamanalp¹
¹Department Of General Surgery, Faculty Of Medicine, Atat�rk University, Erzurum
²Department Of Biochemistry, Faculty Of Medicine, Atat�rk University, Erzurum

BACKGROUND: Cholelithiasis is a frequently encountered problem in developed countries. Gallstone is present in at least 10% of the adults. While 40�60% of people with gallstones manifest an asymptomatic clinical course, in most of the cases with symptomatic cholelithiasis, there is also an asymptomatic period. 20% of the patients with symptomatic gallstones are admitted to emergency services with clinical features of acute cholecystitis. In this study, our aim was to evaluate the diagnostic value of pentraxin 3 on complications and prognosis and also to reduce the morbidity and mortality rates in cases with acute cholecystitis.
METHODS: This study was conducted on patients diagnosed with acute calculous cholecystitis and operated on between September 2012 and January 2014, in the Department of General Surgery of Atat�rk University Medical Faculty. Forty-five patients with ages above 18, who were clinically and radiologically diagnosed with acute calculous cholecystitis (Group I) and 45 healthy people, older than 18 (Group II) were included into the study. Patients were randomly selected.
RESULTS: In our study, although the plasma pentraxin 3 (PTX3) levels were increased in the patient group and also in patients who developed morbidity, this was not statistically significant. PTX3 values were determined to be significantly increased in older patients (p<0.05). Moreover, when the duration of hospital stays were compared, PTX3 was found to be significantly higher in patients hospitalized for longer periods (p<0.05).
CONCLUSION: PTX3 levels were found to be elevated in all evaluated parameters in patients with acute cholecystitis. Therefore, PTX3 level may be a valuable indicator in diagnosis and also in predicting prognosis.

Keywords: Acute cholecystitis, morbidity; mortality; pentraxin 3.

Sorumlu Yazar: Bunyami Ozogul, T�rkiye
Makale Dili: �ngilizce

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