Hızlı Arama
DENEYSEL TIKANMA İKTERİNDE NÖTROFİL FAGOSİTOZUNA GRANÜLOSİT KOLONİ SİTUMULAN FAKTÖRÜN (G-CSF) ETKİLERİ
Bekir Aldemir1, Zafer Cantürk1, Gül İlbay2, Deniz Şahin2, Mustafa Dülger11Kocaeli University, Medical School, Department Of Genaral Surgery, Kocaeli, Turkey2Kocaeli University, Medical School, Department Of Physiology, Kocaeli, Turkey
EFFECTS OF GRANULOCYTE COLONY-STIMULATING FACTOR (G-CSF) ON NEUTROPHIL PHAGOCYTOSIS DURING EXPERIMENTAL OBSTRUCTIVE JAUNDICE
Bekir Aldemir1, Zafer Cantürk1, Gül İlbay2, Deniz Şahin2, Mustafa Dülger11Kocaeli University, Medical School, Department Of Genaral Surgery, Kocaeli, Turkey2Kocaeli University, Medical School, Department Of Physiology, Kocaeli, Turkey
BACKGROUND: Obstruction ofthe extrahepati(biliary tree produces profound depression of many components ofthe immune system. G-CSF improves diseasedfiınction fneutrophils in various conditions. In this study, we planned to investigate the changes on neutrophil phagocytosis in obstruct;ve jaundice and the effect ofG-CSF adm;nistration on thisfiınction.
METHODS: Rats were divided into 5 groups as follows: the sham group and four other groups that underwent double ligation and division of common bile duct. Two of these four groups (Group 3 and 5) received G-CSF during experiment. Neutrophil hagocytosis index was determinedforgroup2and 3 attheend ofthe 15 daysand forgroup 1, 4and 5 attheend of the21 days.
RESULTS: Neutrophil phagocytosis index significantly increased at the end ofthe 15th day after the bile duct ligation (Group 2) and significantly decreased at the end ofthe 21th day after the bile duct ligation (Group 4). Neutrophil phagocytosis index in G-CSF-treated groups was significantly increased at the end ofthe 15'h days (Group 3) and increased at the end of the 21th day (Group 5).
CONCLUTION: As a result, neutrophil phagocytosis index is improved if G-CSF is administered later in the course of prolonged jaundice.
Makale Dili: İngilizce