Ulus Travma Acil Cerrahi Derg. 2011; 17(1): 14-18 | DOI: 10.5505/tjtes.2011.31391

Sýçanlarda spinal kord yaralanmsýnda curcuminin antioksidan etkileri

Havva Sahin Kavakli¹, Cemile Koca², Ozlem Alici^3
1Ankara Atatürk Eðitim Ve Araþtýrma Hastanesi, Acil Týp Kliniði, Ankara,
²Fatih Üniversitesi, Týp Fakültesi, Biyokimya Departmaný, Ankara
³Medikal Park Hastanesi, Enfeksiyon Hastalýklarý Ve Klinik Mikrobiyoloji Departmaný, Ýstanbul, Türkiye

AMAÇ
Bu deneysel çalýþma, sýçanlarda spinal kord yaralanmasýnda curcuminin antioksidan etki yoluyla faydasýný araþtýrmak için yapýldý.
GEREÇ VE YÖNTEM
Yirmi dört adet Wistar albino sýçan 3 gruba randomize edildi. Spinal kord yaralanmasý aðýrlýk düþürme modeliyle gerçekleþtirildi. Grup 1’e laminektomi ardýndan spinal kord yaralanmasý uygulandý ve herhangi bir tedavi verilmedi. Grup 2’ye laminektomi ardýndan spinal kord yaralanmasý uygulandý ve curcumin verildi (200 mg/kg/gün aðýzdan). Grup 3’e laminektomi ardýndan spinal kord yaralanmasý uygulandý ve metilprednizolon verildi (30 mg/kg periton içine), 24 saat sonra tüm sýçanlardan kan örnekleri alýndý, sonra serum süperoksit dismutaz (SOD) ve malondialdehit (MDA) düzeyleri belirlendi ve elde edilen sonuçlar karþýlaþtýrýldý.
BULGULAR
Curcumin grubunda SOD düzeyi kontrol ve metilprednizolon grubundan daha yüksekti (p<0,001 ve p<0,012). Curcumin grubunda MDA düzeyi kontrol grubundan daha düþüktü (p<0,042). Benzer þekilde metilprednizolon grubunda MDA düzeyi kontrol grubundan daha düþüktü (p<0,001).
SONUÇ
Bu çalýþmanýn sonuçlarý curcuminin etkin biçimde oksidatif hasara karþý spinal kord dokularýný koruduðunu gösterir.

Anahtar Kelimeler: Antioksidan, curcumin; malondialdehit; spinal kord yaralanmasý; süperoksit dismutaz.

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Antioxidant effects of curcumin in spinal cord injury in rats

Havva Sahin Kavakli¹, Cemile Koca², Ozlem Alici^3
1Ankara Ataturk Training And Research Hospital, Department Of Emergency, Ankara, Turkey
²Fatih University, Faculty Of Medicine, Department Of Biochemistry, Ankara, Turkey
³Medical Park Hospital, Department Of Infectious Diseases And Clinical Bacteriology, Istanbul, Turkey

BACKGROUND
This experimental study was performed to investigate the benefit of curcumin via its antioxidant effect on spinal cord injury (SCI) in rats.
METHODS
Twenty-four adult Wistar albino rats were randomized into three groups. SCI was performed by the weight-drop model. Group 1 underwent laminectomy followed by SCI and received no medication. Group 2 underwent laminectomy followed by SCI and received curcumin (200 mg/kg/day orally). Group 3 underwent laminectomy followed by SCI and received methylprednisolone (30 mg/kg intraperitoneally). Twenty-four hours later, blood samples were obtained from all rats; serum superoxide dismutase (SOD) and malondialdehyde (MDA) levels were determined, and the obtained results were compared.
RESULTS
SOD level in the curcumin group was higher than in the control group (p<0.000) and methylprednisolone group (p<0.012). MDA level in the curcumin group was lower than in the control group (p<0.042). Similarly, the MDA level in the methylprednisolone group was lower than in the control group (p<0.001).
CONCLUSION
The results of the present study show that curcumin effectively protects the spinal cord tissues against oxidative damage.

Keywords: Antioxidant, curcumin; malondialdehyde; spinal cord injury; superoxide dismutase.

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ATIF KOPYALA