Ulus Travma Acil Cerrahi Derg. 2020; 26(1): 37-42 | DOI: 10.14744/tjtes.2019.38969

Akut pankreatitli hastalarda tiyol-disülfit dengesi ve diðer kan parametreleri ile iliþkisi

Fadime Güllü Ercan Haydar¹, Yavuz Otal², Alp Þener², Gül Pamukçu Günaydýn², Ferhat Içme², Tuðba Atmaca Temrel², Pervin Baran³, Ozcan Erel^4
1Ataturk Training and Research Hospital, General Surgery Department, Ankara
²Atatürk Eðitim Ve Araþtýrma Hastanesi,Acil Týp Kliniði, Ankara
³Atatürk Eðitim Ve Araþtýrma Hastanesi,Týbbi Biyokimya Kliniði, Ankara
⁴Yýldýrým Beyazýt Üniversitesi, Týbbi Biyokimya AnaBilimDalý, Ankara

AMAÇ: Akut pankreatit (AP) karýn aðrýsý nedeniyle acil serviste sýklýkla görülen bir hastalýktýr. Bu çalýþma AP tanýsý konulan hastalarda, kanda tiyol-disülfit parametrelerinin ölçümü ve diðer kan parametreleri ile iliþkisinin deðerlendirilmesi amaçlandý.
GEREÇ VE YÖNTEM: Çalýþmaya acil servise baþvuran 56 (%56) hasta ve 44 (%44) saðlýklý gönüllü olmak üzere toplam 100 örnek alýndý. Hastalardan geliþ anýnda detaylý kan örnekleri alýndý. Akut pankreatit tanýsý konan hastalarýn baþvurusu sýrasýnda ki venöz kan örneklerinden Erel ve Neþelioðlu tarafýndan geliþtirilen yepyeni bir yöntemle serumda tiyol-disülfide düzeyi çalýþýldý. Veriler bilgisayar ortamýnda deðerlendirildi.
BULGULAR: Akut pankreatitin etiyolojisi 41 hastada (%73.2) safra taþý, bir hastada (%1.7) hipertrigliseridemi, dört hastada (% 7.1) alkol kullanýmý ve 10 hastada (%17.8) idiyopatik idi. Kan tiyol düzeyleri düþük iken, disülfide düzeyleri anlamlý derecede yüksekti. Diðer kan parametreleri olan amilaz, lipaz, NLR (nötrofil lenfosit oraný) ile tiyol-disülfide dengesi parametreleri arasýnda istatistiki açýdan anlamlý fark bulunamadý.
TARTIÞMA: Akut pankreatit de patogenezde tiyol-disülfit dengesinin bozulmasý rol oynayabilir. AP’de kanda tiyol düzeyi azaldýðýndan bu tiyol eksikliðini tamamlayýcý tedavilerin verilmesi hastalýðýn iyileþmesine katkýda bulunabilir.

Anahtar Kelimeler: Akut pankreatit, oksidatif stres; tiyol-disülfid dengesi.

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The thiol-disulphide homeostasis in patients with acute pancreatitis and its relation with other blood parameters

Fadime Güllü Ercan Haydar¹, Yavuz Otal², Alp Þener², Gül Pamukçu Günaydýn², Ferhat Içme², Tuðba Atmaca Temrel², Pervin Baran³, Ozcan Erel^4
1Department of General Surgery, Atatürk Training and Research Hospital, Ankara-Turkey
²Department of Emergency Medicine, Atatürk Training and Research Hospital, Ankara-Turkey
³Department of Medical Biochemistry, Atatürk Training and Research Hospital, Ankara-Turkey
⁴Department of Medical Biochemistry, Yýldýrým Beyazýt University Faculty of Medicine, Ankara-Turkey

BACKGROUND: Acute pancreatitis is a common disease seen in emergency departments because of abdominal pain. The present study aims to evaluate the relation between measurements of thiol-disulfide parameters in patients diagnosed with acute pancreatitis and other blood parameters.
METHODS: A total of 56 (56%) patients, who were admitted to the emergency department, and 44 (44%) healthy volunteers participated in this study. A total of 100 samples were taken from the participants. Detailed blood samples were taken from the patients at the time of arrival at the hospital. The thiol-disulfide level in serum was examined using a brand new method that was developed by Erel and Neþelioðlu in the venous blood samples of the patients who were diagnosed with acute pancreatitis during the admission. The data were evaluated in the computer medium.
RESULTS: Gallstones were defined as the etiology of AP in 41 patients (73.2%); in one patient, hypertriglyceridemia (1.7%); in four patients, alcohol use (7.1%), and idiopathic 10 patients (17.8%). While the blood thiol levels were low, the disulfide levels were high at a significant level. No statistically significant relations were detected between the amylase, lipase, neutrophil lymphocyte ratio (NLR), which are other blood parameters, and thiol-disulfide balance parameters.
CONCLUSION: The disruption of the thiol-disulfide balance may play a role in the pathogenesis of acute pancreatitis. In acute pancreatitis, since the thiol level is decreased in the blood, administration of the complementary therapies for this thiol deficiency may contribute to the treatment of the disease.

Keywords: Acute pancreatitis, oxidative stress; thiol-disulphide homeostasis.

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