RESULTS OF GLUTATHIONE UPTAKE SCANNING IN SEPTIC RATS

Critical illness such as sepsis, trauma and shock is associated with both immunosupression and glutathione (GSH) deficiency. Liver is a target organ during sepsis because of this. Hepatic GSH levels decrease due to sepsis. We have investigated the level of hepatic GSH during sepsis by Tc 99m GSH scanning. Sepsis was induced in rats by cecal ligation and puncture following 24 hours of sepsis, Tc 99m GSH was administered by cardiac puncture and hepatic GSH uptake scanning was performed. As a result no significant changes of hepatic GSH uptakes was determined by Tc 99m GSH in sepsis.

SEPTÝK SIÇANLARDA KARACÝÐER GLUTATHÝONE UPTAKE SÝNTÝGRAFÝSÝ SONUÇLARI

Sepsis, travma ve þok gibi kritik hastalýklarda immünosüpresyon, glutathione (GSH) yetmezliði ile birliktedir. Bu yüzden sepsiste karaciðer hedef organdýr ve sepsiste hepatik GSH düzeyleri düþer. Bu çalýþmada sepsis esnasýnda hepatik GSH düzeylerini Tc 99m GSH sintigrafisi ile inceledik. Sýçanlardaki sepsis, çekal ligasyon ve perforasyon yöntemi ile yapýldý. Sepsisten 24 saat sonra intrakardiak yolla Tc 99m GSH verildi ve hepatik GSH uptake sintigrafisi yapýldý. Sonucunda sepsiste hepatik GSH uptake'inde anlamlý bir deðiþiklik bulunamadý.