Akut pankreatitte iskemi modifiye alb�min ve Ranson skoru aras�ndaki korelasyon

G�ldo�an, Cem Emir; K�l��, Murat �zg�r; Balamir, �lhan; Tez, Mesut; Turhan, Turan

Cilt : 23 Say� : 6 Y�l : 2024

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Akut pankreatitte iskemi modifiye alb�min ve Ranson skoru aras�ndaki korelasyon [Ulus Travma Acil Cerrahi Derg]

Ulus Travma Acil Cerrahi Derg. 2017; 23(6): 472-476 | DOI: 10.5505/tjtes.2017.51499

Akut pankreatitte iskemi modifiye alb�min ve Ranson skoru aras�ndaki korelasyon

Cem Emir G�ldo�an¹, Murat �zg�r K�l��¹, �lhan Balamir², Mesut Tez¹, Turan Turhan²
¹Numune E�itim ve Ara�t�rma Hastanesi, Genel Cerrahi Klini�i, Ankara
²Ankara Numune E�itim ve Ara�t�rma Hastanesi, Biyokimya Laboratuvar�, Ankara

AMA�: Ranson skoru akut pankreatitin (AP) �iddetinde en yayg�n kullan�lan prognostik model olmas�na kar��n, iskemi modifiye alb�min (�MA) son y�llarda �e�itli iskemi temelli hastal�klar i�in yeni bir belirte� olarak bildirilmi�tir. Ama� AP hastalar�nda Ranson skoru ve �MA aras�ndaki korelasyonu ara�t�rmakt�r.
GERE� VE Y�NTEM: K�rk �� AP hastas� �al��maya dahil edildi. T�m hastalar hafif ve �iddetli AP olarak s�n�fland�r�ld�. Plazma �MA seviyesi tan�dan sonra ve tedaviden �ncesi �l��ld�. �skemi modifiye alb�min d�zeyi ile amilaz d�zeyi, Ranson skoru ve hastal��n �iddeti aras�ndaki ili�ki de�erlendirildi.
BULGULAR: Yirmi dokuz (%67.4) hastaya hafif AP tan�s� konarken, 14 (%32.6) hasta orta �iddetli veya �iddetli hastal�k formuna sahipti ve �iddetli AP olarak s�n�fland�r�ld�. Hasta gruplar� aras�nda �MA d�zeylerinde anlaml� bir fark yoktu (p=0.737). �skemi modifiye alb�min d�zeyleri ile amilaz d�zeyleri (p=0.470), Ranson skoru (p=0.664) ve hastal�k �iddeti (p=0.741) aras�nda korelasyon saptanmad�.
TARTI�MA: �al��madan elde edilen sonu�lara g�re, �MA AP�de hastal�k �iddetinin erken tahmininde yararl� bir belirte� olarak g�r�nmemektedir. �nemli dezavantajlar�na ra�men, Ranson skoru hastal��n �iddetini daha do�ru g�stermektedir.

Anahtar Kelimeler: Akut pankreatit, hastal�k �iddeti, iskemi modifiye albumin

Correlation between ischemia-modified albumin and Ranson score in acute pancreatitis

Cem Emir G�ldo�an¹, Murat �zg�r K�l��¹, �lhan Balamir², Mesut Tez¹, Turan Turhan²
¹Department of General Surgery, Numune Training and Research Hospital, Ankara-Turkey
²Department of Biochemistry, Numune Training and Research Hospital, Ankara-Turkey

BACKGROUND: Although Ranson score is the most commonly used prognostic model in the severity of acute pancreatitis (AP), ischemia-modified albumin (IMA) has been reported as a novel biomarker of various ischemia-based diseases in recent years. The aim of the present study is to investigate the correlation between Ranson score and IMA in patients with AP.
METHODS: Forty-three patients with AP were included in the study. All patients were classified as mild and severe AP. Plasma IMA level was measured after diagnosis and before treatment. The correlation between IMA level and amylase level, Ranson score, and disease severity was evaluated.
RESULTS: Twenty-nine (67.4%) patients were diagnosed as mild AP; the remaining 14 (32.6%) patients had moderately severe or severe form of disease, and were classified as severe AP. There was no significant difference in the IMA levels between the patient groups (p=0.737). No correlation between IMA levels and amylase levels (p=0.470), Ranson score (p=0.664), and disease severity (p=0.741) was found.
CONCLUSION: According to the results from the study, IMA does not seem as a useful marker in earlier prediction of disease severity in AP. Despite important disadvantages, Ranson score still indicates the disease severity more accurately.

Keywords: Acute pancreatitis, ischemia-modified albumin, disease severity.

Sorumlu Yazar: Murat �zg�r K�l��, T�rkiye
Makale Dili: �ngilizce

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