p-ISSN: 1306-696x | e-ISSN: 1307-7945
Volume : 27 Issue : 4 Year : 2021

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EFFECTS OF HYPERTONIC SALINE, HAES AND DIMETHYLSULPHOXIDE ON FREE OXYGEN RADICALS IN HAEMORRHAGIC SHOCK OXYGEN RADICALS IN HAEMORRHAGIC SHOCK [Ulus Travma Acil Cerrahi Derg]
Ulus Travma Acil Cerrahi Derg. 2003; 9(3): 154-159

EFFECTS OF HYPERTONIC SALINE, HAES AND DIMETHYLSULPHOXIDE ON FREE OXYGEN RADICALS IN HAEMORRHAGIC SHOCK OXYGEN RADICALS IN HAEMORRHAGIC SHOCK

Emrah Karagözoğlu1, Mehmet Gül2, Kaan Karabulut3, Ayşegül Bayır2, M. Ertuğrul Kafalı2, Ahmet Ak2, Mustafa Şahin4
1Meram Medical Faculty of Selçuk University Biochemistry Department, Konya, Turkey
2Meram Medical Faculty of Selçuk University Emergency Department, Konya, Turkey
3Meram Medical Faculty of Selçuk University Anatomy Department, Konya, Turkey
4Meram Medical Faculty of Selçuk University General Surgery Department, Konya, Turkey

Background: The aim of this study was to investigate the effects of antioxidant and resuscitation fluids which were used during haemorrhagic shock on tissue ischemia.
Methods: Forty New Zealand type rabbits were divided into four groups as C (control), I (hypertonic saline), H (HAES) and D (Dymethylsulphdxide-DMSO). Haemorrhagic shock was induced by bleeding from carotid artery. Thirty minutes after shock, Group C was not resuscitated while Group I was resuscitated with Hypertonic saline 7.2, Group H with 10 % HAES and Group D with HAES 10 % and DMSO. Thiobarbituric acid reactive substances (TBARS) and lactate levels in blood, liver and small bowel samples were measured.
Results: There were no significant differences among the groups tissue and plasma TBARS and lactate levels.
Conclusion: Resuscitation fluids and addition of antioxidants to the resuscitation fluids do not have any superiorities over each other to prevent tissue ischemic insult in haemorrhagic shock.

Keywords: Haemorrhagic shock, hypertonic saline, oxygen free radicals, imethylsulphoxide, antioxidants

HEMORAJİK ŞOKTA OKSİJEN SERBEST RADİKALLERİ ÜZERİNE HİPERTONİK SALİN, HAES VE DİMETİLSÜLFOKSİT’İN ETKİLERİ

Emrah Karagözoğlu1, Mehmet Gül2, Kaan Karabulut3, Ayşegül Bayır2, M. Ertuğrul Kafalı2, Ahmet Ak2, Mustafa Şahin4
1Meram Medical Faculty Of Selçuk University Biochemistry Department, Konya, Turkey
2Meram Medical Faculty Of Selçuk University Emergency Department, Konya, Turkey
3Meram Medical Faculty Of Selçuk University Anatomy Department, Konya, Turkey
4Meram Medical Faculty Of Selçuk University General Surgery Department, Konya, Turkey


Emrah Karagözoğlu, Mehmet Gül, Kaan Karabulut, Ayşegül Bayır, M. Ertuğrul Kafalı, Ahmet Ak, Mustafa Şahin. EFFECTS OF HYPERTONIC SALINE, HAES AND DIMETHYLSULPHOXIDE ON FREE OXYGEN RADICALS IN HAEMORRHAGIC SHOCK OXYGEN RADICALS IN HAEMORRHAGIC SHOCK. Ulus Travma Acil Cerrahi Derg. 2003; 9(3): 154-159