p-ISSN: 1306-696x | e-ISSN: 1307-7945
Volume : 9 Supp : 3 Year : 2021

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Turkish Journal of Trauma and Emergency Surgery THE RELATIONSHIP BETWEEN THE LEVEL OF THIRTEEN DIFFERENT SUBSTANCES AND ENZYMES IN BLOOD AND PERITONEAL FLUID AND THE DURATION OF MECHANICAL INTESTINAL OBSTRUCTION: AN EXPERIMENTAL STUDY ON RATS [Ulus Travma Acil Cerrahi Derg]
Ulus Travma Acil Cerrahi Derg. 2003; 9(3): 183-188

THE RELATIONSHIP BETWEEN THE LEVEL OF THIRTEEN DIFFERENT SUBSTANCES AND ENZYMES IN BLOOD AND PERITONEAL FLUID AND THE DURATION OF MECHANICAL INTESTINAL OBSTRUCTION: AN EXPERIMENTAL STUDY ON RATS

Hakan Yıldız1, Mustafa Oncel1, Necmi Kurt1, Selahattin Vural1, Cem Gezen1, Gulay Dalkılıc1, Engin Olcay1
General Surgery Service, Kartal Dr. Lutfi Kirdar Education and Research Hospital, Istanbul, Turkey

Purpose: The aim of this study is to analyze the relationship between the changes in blood and peritoneal fluid and the duration of mechanical intestinal obstruction.
Methods: A mechanical intestinal obstruction was surgically carried out in 52 Wistar albino rats. The blood and peritoneal fluid were sampled immediately (Group 1, n=13), and at 6 hours (Group 2, n=13), at 24 hours (Group 3, n=13), and at 48 hours (Group 4, n=13) following the procedure.
Results: Blood and peritoneal fluid ammonia concentrations, as well as blood aldolase activity have risen progressively over time (p<0.05), although not all pair-wise comparisons were statistically significant (P>0.05).
Conclusions: Our data suggest that peritoneal fluid and blood ammonia levels and blood aldolase levels rise according to duration of the intestinal obstruction. Since the results were not available to determine cut-off levels, future research is required to confirm these results and determine whether ammonia or aldolase can be used in clinical practice to predict the presence and duration of a mechanical intestinal obstruction.

Keywords: Ammonia, aldolase, mechanical intestinal obstruction

Hakan Yıldız, Mustafa Oncel, Necmi Kurt, Selahattin Vural, Cem Gezen, Gulay Dalkılıc, Engin Olcay. THE RELATIONSHIP BETWEEN THE LEVEL OF THIRTEEN DIFFERENT SUBSTANCES AND ENZYMES IN BLOOD AND PERITONEAL FLUID AND THE DURATION OF MECHANICAL INTESTINAL OBSTRUCTION: AN EXPERIMENTAL STUDY ON RATS. Ulus Travma Acil Cerrahi Derg. 2003; 9(3): 183-188