p-ISSN: 1306-696x | e-ISSN: 1307-7945
Volume : 9 Issue : 2 Year : 2024

Quick Search




SCImago Journal & Country Rank
Turkish Journal of Trauma and Emergency Surgery THE EFFECTS OF L-TRYPTOPHAN AND PENTOXIPHYLLINE ON STRESS ULCER [Ulus Travma Acil Cerrahi Derg]
Ulus Travma Acil Cerrahi Derg. 2003; 9(2): 90-95

THE EFFECTS OF L-TRYPTOPHAN AND PENTOXIPHYLLINE ON STRESS ULCER

Nurullah Bülbüller1, M. Ali Akkuş1, Y. Selim İlhan1, Feridun Baysal1, İbrahim Özercan2, Erhan Aygen1, Cüneyt Kırkıl1
1Fırat Universitesi Tıp Fakültesi, Fırat Tıp Merkezi, Genel Cerrahi Anabilim Dalı, Elazığ, Turkey
2Fırat Üniversitesi Tıp Fakültesi, Fırat Tıp Merkezi, Patoloji. Anabilim Dalı, Elazığ, Turkey

Background: It is well known that stress leads to the formation of gastric mucosal lesions. Free oxygen radicals play an important role in the pathogenesis of inflammation and tissue damage. It was observed that L-tryptophan has a positive effect on gastric mucosal damage in ischemia-reperfusion injury by inhibition of free oxygen radicals. The protective effect of pentoxifylline was shown in gastric mucosal damage induced by ischemia - reperfusion or the application of some topical agents.We performed an experimental study to determine whether intragastric L-tryprophan and intramuscular
pentoxifylline protect gastric mucosal damage that is induced by immobility stress.
Methods: Forty rats were immobilized and divided into four groups. No treatment was made in the first group; in group 2,3 and 4, L-tryptophan, pentoxifylline and L-tryptophan + pentoxifylline were administered, respectively. The gastric lesions were assesed macroscopically and microscopically two hours following treatment.
Results: In the second and fourth groups, the lesion surface area and average mucosal damage were fewer in comparison to the control group (p<0,03). Moreover, an histopatologically improvement in the surface epithelium was observed in these groups. The average lesion score also reduced significantly (p<0,03) only in the L-tryptophan group. On the other hand, no statistically significant improvement was observed in the pentoxifylline group.
Conclusion: As a result, it was concluded that L-tryptophan could play a protective role in the gastric mucosal damage associated with stress.

Keywords: Stress ulcer, L-tryptophan, Pentoxifylline.

L-TRİPTOFAN VE PENTOKSİFİLİNİN ÜLSERİ ÜZERİNE ETKİSİ

Nurullah Bülbüller1, M. Ali Akkuş1, Y. Selim İlhan1, Feridun Baysal1, İbrahim Özercan2, Erhan Aygen1, Cüneyt Kırkıl1
1Fırat Universitesi Tıp Fakültesi, Fırat Tıp Merkezi, Genel Cerrahi Anabilim Dalı, Elazığ, Turkey
2Fırat Üniversitesi Tıp Fakültesi, Fırat Tıp Merkezi, Patoloji. Anabilim Dalı, Elazığ, Turkey


Nurullah Bülbüller, M. Ali Akkuş, Y. Selim İlhan, Feridun Baysal, İbrahim Özercan, Erhan Aygen, Cüneyt Kırkıl. THE EFFECTS OF L-TRYPTOPHAN AND PENTOXIPHYLLINE ON STRESS ULCER. Ulus Travma Acil Cerrahi Derg. 2003; 9(2): 90-95

Corresponding Author: Nurullah Bülbüller
Manuscript Language: Turkish