p-ISSN: 1306-696x | e-ISSN: 1307-7945
Volume : 19 Supp : 6 Year : 2021

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Turkish Journal of Trauma and Emergency Surgery The role of thoracic trauma in inflammatory responses, apoptosis and bacterial translocation following multipl trauma [Ulus Travma Acil Cerrahi Derg]
Ulus Travma Acil Cerrahi Derg. 2013; 19(6): 491-499 | DOI: 10.5505/tjtes.2013.29660

The role of thoracic trauma in inflammatory responses, apoptosis and bacterial translocation following multipl trauma

Erhan Ayan1, Oguz Koksel1, Ayşe Polat2, Lülüfer Tamer3, Gülden Ersöz4, Murat Demir1, Hatice Yıldırım Yaroğlu3, Alper Akdağ4, Ali Özdülger1, Sema Erden5
1Department Of Thoracic Surgery, Mersin, Turkey
2Department Of Pathology, Mersin, Turkey
3Department Of Biochemistry, Mersin, Turkey
4Department Of Infectious Disease, Mersin, Turkey
5Health Occupation High School, Biostatistics, Phd, Mersin, Turkey

Background: Blunt chest trauma and its complications are common clinical problems in emergency medicine. We used a rat model for to investigate the evolution thoracic trauma role of inflammation, apoptosis and bacterial translocation in multiple traumas.
Materials and Methods: 90 Wistar rats were divided nine groups. Rats were performed a standardized blunt thoracic and/or head trauma and sacrified 24, 48 hours after the trauma. Multiple specimens from different organs and blood samples were collected and quantitatively cultured for aerobic organisms. Interleukins, TNF-α, MCP-1 levels were assessed in sera and apoptosis in lungs.
Results: Levels of interleukins, TNF-α and MCP-1 in all trauma groups significantly increased compared to control groups (p=0,001). Levels of apoptotic cell in head and thoracic trauma (HTT) groups significantly increased compared to respective Control group (p=0,009). Light microscopic evaluating of all groups, damage significantly increased in HTT groups compared to C group. The incidence of bacterial translocation was significantly higher in HTT group (p=0,003).
Conclusions: Multitude of inflammatory mediators is activated in multiple traumas including blunt thoracic trauma and bacterial translocation and apoptotic process to be formed. We believe plays major role of thoracic truma in post traumatic bacterial tranlocation inflammation and apoptozis after the multipl trauma.

Keywords: Thoracic Trauma, Head Trauma, Interleukin, Lung Injury, SIRS

Erhan Ayan, Oguz Koksel, Ayşe Polat, Lülüfer Tamer, Gülden Ersöz, Murat Demir, Hatice Yıldırım Yaroğlu, Alper Akdağ, Ali Özdülger, Sema Erden. The role of thoracic trauma in inflammatory responses, apoptosis and bacterial translocation following multipl trauma. Ulus Travma Acil Cerrahi Derg. 2013; 19(6): 491-499

Corresponding Author: Erhan Ayan, Türkiye