Ulus Travma Acil Cerrahi Derg. 2008; 14(2): 96-102

Stres gastriti oluþumunda düþük tiroit hormon düzeylerinin etkisi: Sýçanlar üzerinde deneysel bir çalýþma

Göktürk Maralcan¹, Hayri Erkol², Zerrin Erkol³, Fatih Yanar⁴, Rebecca Plevin^5
1Gaziantep Üniversitesi Týp Fakültesi Genel Cerrahi Anabilim Dalý, Gaziantep,
²Abant Ýzzet Baysal Üniversitesi Týp Fakültesi Genel Cerrahi Anabilim Dalý, Bolu,
³Abant Ýzzet Baysal Üniversitesi Týp Fakültesi Adli Týp Anabilim Dalý, Bolu,
⁴Ýstanbul Üniversitesi, Ýstanbul Týp Fakültesi, Genel Cerrahi Ana Bilim Dalý, Ýstanbul
⁵Los Angeles County, Üniversitesi Of Southern California, Keck School Of Medicine, Los Angeles, Ca, Usa

AMAÇ
Bu çalýþmanýn amacý, sýçanlarda akut stres gastritis geliþmesinde düþük serum tiroit hormon düzeylerinin etkisini araþtýrmaktýr.
GEREÇ VE YÖNTEM
Altmýþ eriþkin Sprague-Dawley cinsi sýçan onarlý altý gruba ayrýldý: Kontrol grubu, cerrahi tiroidektomi grubu, stres grubu, cerrahi tiroidektomi + stres grubu, cerrahi tiroidektomi + T4 + stress grubu ve cerrahi tiroidektomi + T3 + stres grubu. Gastrik mukoza hasarýnýn sayý ve büyüklüðü milimetrik asetat kaðýdý kullanýlarak 3,5 kez büyütülmüþ fotoðraf üzerinde belirlendi.
BULGULAR
Sadece stres altýnda olan sýçanlar (grup III) ile karþýlaþtýrýldýðýnda cerrahi tiroidektomi + stres grubunda (grup IV) akut stres gastriti, belirgin olarak artmýþtý (stres gastriti skorlarý; grup IV: 44, grup III: 16, p<0,001). Grup IV’teki sýçanlarla karþýlaþtýrýldýðýnda stres gastriti skorunun grup VI’da belirgin olarak azaldýðý gözlendi (stres gastriti skorlarý; grup VI: 10, grup IV: 44, p<0,001).
SONUÇ
Sýçanlarda düþük serum tiroit hormon düzeyleri stres gastritinin geliþmesini artýrmakta ve bu etki, tiroit hormon replasman tedavisi ile önlenebilmektedir.

Anahtar Kelimeler: Düþük T3 hasta sendromu, düþük serum triiyodotironin; hipotiroidi; ötiroid hasta sendromu; sýçan, Sprague-Dawley cinsi; stres gastriti; travma.

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The effects of low thyroid hormone levels on the formation of stress gastritis: an experimental study on the rats

Göktürk Maralcan¹, Hayri Erkol², Zerrin Erkol³, Fatih Yanar⁴, Rebecca Plevin^5
1Department Of General Surgery,faculty Of Medicine, Gaziantep University, Gaziantep Turkey
²Department Of General Surgery, Faculty Of Medicine, Abant Ýzzet Baysal University, Bolu Turkey
³Department Of Forensic Medicine, Faculty Of Medicine, Abant Ýzzet Baysal University, Bolu Turkey
⁴Depertment Of General Surgery, Istanbul University Istanbul Faculty Of Medicine, Istanbul, Turkey
⁵Los Angeles County, University Of Southern California,keck School Of Medicine, Los Angeles, Ca, Usa

BACKGROUND
The aim of this study was to investigate the effect of low circulating thyroid hormone levels on the development of acute stress gastritis in rats.
METHODS
Sixty adult Sprague-Dawley rats were divided into six groups: Control group, surgically thyroidectomized group, stressed group, surgically thyroidectomized + stressed group, surgically thyroidectomized + T4 + stressed group, and surgically thyroidectomized + T3 + stressed group. Damage to the gastric mucosa was studied using millimetric acetate papers on photographs enlarged 3.5 times and the number and the size of the lesions was recorded.
RESULTS
Acute stress gastritis was significantly increased in stress + surgically thyroidectomized rats as compared to rats that were only put under stress (group III) (stress gastritis scores; group IV: 44, group III: 16, p<0.001). The stress gastritis score in group VI was significantly decreased compared to rats in group IV (stress gastritis scores; group VI: 10, group IV: 44, p<0.001).
CONCLUSION
Low circulating thyroid hormone levels in rats increased the development of stress gastritis. This effect could be prevented by thyroid hormone replacement therapy.

Keywords: Euthyroid sick syndrome, hypothyroidism; low serum triiodothyronine; low T3 sick syndrome; rats, Sprague-Dawley; stress gastritis; trauma.

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