Ulus Travma Acil Cerrahi Derg. 2014; 20(4): 231-235 | DOI: 10.5505/tjtes.2014.63993

Travmatik Yaralarda Oral Antibiyotiklerin Enfeksiyon Profilaksisindeki Etkileri

Bülent Erbil¹, Gürkan Ersoy², Aydan Özkütük³, Funda Karbek Akarca², Tanzer Korkmaz², Ömer Faruk Demir², Selahattin Kýyan^2
1Hacettepe Üniversitesi, Týp Fakültesi, Acil Týp Anabilim Dalý, Ankara, Türkiye
²Dokuz Eylül Üniversitesi, Týp Fakültesi, Acil Týp Anabilim Dalý, Ýzmir, Türkiye
³Dokuz Eylül Üniversitesi, Týp Fakültesi, Týbbi Mikrobiyoloji Anabilim Dalý, Ýzmir, Türkiye

AMAÇ: Bu çalýþmanýn amacý, travmatik yaralarda enfeksiyon geliþiminin önlenmesinde oral antibiyotiklerin etkinliðini incelemektir.
GEREÇ VE YÖNTEM: Kýrk adet Wistar albino rat sekizerli beþ gruba ayrýldý. Ratlarýn sýrtýnda ezik yara modeli oluþturulduktan sonra, yaralar basit sütür ile kapatýldý. Staphylococcus aureus ATCC 29213 suþlarý enfeksiyon oluþturulmak için kullanýldý. Kontrol grubu dýþýndakilere oral gavaj ile beþ gün sefaleksin, amoksisilin-klavulanat, klaritromisin ve levofloksasini içeren antibiyotikler verildi. Yaralar, son tedavi verildikten sonra 18. saatinde kalitatif ve kantitatif olarak deðerlendirildi.
BULGULAR: Kantitatif deðerlendirmede amoksisilin-klavulanat, klaritromisin, sefaleksin, levofloksasin ile tedavi edilen gruplarda enfeksiyon tespit edilmedi. Guruplar arasýnda yaralardaki bakteri sayýsý açýsýndan anlamlý fark bulunmadý. Kantitatif inflamasyon bulgularýna göre deðerlendirildiðinde, medikasyon uygulanan dört grubun hiçbirinde hiperemi ve püy belirlenmedi. Endürasyon açýsýndan gruplar arasýnda anlamlý fark bulunmadý.
SONUÇ: Ratlarda Staphylococcus aureus ile oluþturduðumuz enfekte travmatik ezik yara modelinde; oral proflaktik antibiyotiklerin yara enfeksiyonunu önlemede etkin olduðu bulunmuþtur.

Anahtar Kelimeler: Travmatik yara, yara enfeksiyonu, profilaksi, antibiyotik

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The Effects of Oral Antibiotics on Infection Prophylaxis in Traumatic Wounds

Bülent Erbil¹, Gürkan Ersoy², Aydan Özkütük³, Funda Karbek Akarca², Tanzer Korkmaz², Ömer Faruk Demir², Selahattin Kýyan^2
1Department Of Emergency Medicine, Faculty Of Medicine, Hacettepe University, Ankara, Turkey
²Department Of Emergency Medicine, Faculty Of Medicine, Dokuz Eylul University, Izmir, Turkey
³Department Of Medical Microbiology, Dokuz Eylul University, Faculty Of Medicine, Izmir, Turkey

BACKGROUND: The objective of this study is to examine the effectiveness of oral antibiotics in the prevention of infection development in traumatic wounds.
METHODS: Forty Wistar albino rats were divided into five groups of eight animals. After the crushed wound model was made on the back of the rats, wounds were closed with a simple suture and Staphylococcus aureus ATCC 29213 strain was used to create infection. All rats apart from the controls were given oral gavage with antibiotics including cephalexin, amoxicillin-clavulanate, clarithromycin or levofloxacin for five days. Wounds were evaluated qualitatively and quantitatively on fifth day approximately 18 hours after the last treatment.
RESULTS: In the quantitative evaluation, no infection was observed in the treatment groups with amoxicillin-clavulanate, clarithromycin, cephalexin or levofloxacin. There was no significant difference on the numbers of bacteria found in the wounds among the groups. In terms of quantitative inflammation findings, no hyperemia or pus was detected in the groups that were given medication. Also no statistically significant difference was found among the groups in terms of induration.
CONCLUSIONS: Oral prophylactic antibiotics have been found to be effective in the prevention of wound infection in the traumatic crushed wound model infected with Staphylococcus aureus in rats.

Keywords: Antibiotic, prophylaxis, traumatic wound, wound infection

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