Ulus Travma Acil Cerrahi Derg. 2011; 17(6): 482-487 | DOI: 10.5505/tjtes.2011.75428

Ýskemik kolon anastomozunun iyileþmesi üzerine pentoksifilin ve vinposetinin etkisi: Deneysel çalýþma

Aziz Sümer¹, Ediz Altinli², Serkan Senger², Neþet Köksal², Ender Onur³, Ersan Eroðlu², Pembegül Güneþ^4
1Yüzüncü Yýl Üniversitesi, Týp Fakültesi, Genel Cerrahi Kliniði
²Haydarpaþa Numune Eðitim Ve Araþtýrma Hastanesi, 2. Genel Cerrahi Kliniði
³Fatih Sultan Mehmet Eðitim Ve Araþtýrma Hastanesi, Genel Cerrahi Kliniði
⁴Haydarpaþa Numune Eðitim Ve Araþtýrma Hastanesi, Patoloji Kliniði

AMAÇ
Bu çalýþmada, eritrositlerin fleksibilitesini, deformabilitesini ve akýþkanlýðýný arttýran, ayný zamanda trombositlerin agregasyon yeteneklerini azaltan pentoksifilin ile nöroprotektif, antioksidan etkisi olan vinposetinin kolon anastomozlarýnda iyileþme üzerine olan etkileri araþtýrýldý.
GEREÇ VE YÖNTEM
Çalýþmamýzda 30 adet Albino Wistar cinsi sýçan kullanýldý. Denekler herbiri 10 adet sýçandan oluþan 3 gruba ayrýldý. Tüm gruplarda kolon iskemisi oluþturuldu. Kolon transeksiyonu sonrasý anastomoz yapýldý. Grup A’ya intraperitoneal olarak serum fizyolojik, Grup B’ye pentoksifilin ve Grup C’ye ise vinposetin verildi. Cerrahi iþlem sonrasý 5. günde eter anestezisi ile sakrifiye edilen sýçanlarýn kolon patlama basýnçlarý ölçüldü. Anastomoz bölgesi hidroksiprolin ölçümü ve histopatolojik inceleme için çýkartýldý.
BULGULAR
Gruplararasý kolon patlama basýnçlarý kontrol grubuna göre daha yüksek ölçülmekle birlikte, istatistiksel olarak anlamlý deðildi. Gruplararasý doku hidroksiprolin düzeyleri açýsýndan Grup A ile Grup B, Grup A ile Grup C ve Grup B ile Grup C arasýnda istatistiksel olarak anlamlý fark vardý.
SONUÇ
Vinposetinin de pentoksifilin gibi iskemik kolon anastomozlarýna olumlu etkisi olduðu gösterilmiþtir.

Anahtar Kelimeler: Kolon anastomozu, iskemi; pentoksifilin; vinpocetin.

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Effect of pentoxifylline and vinpocetine on the healing of ischemic colon anastomosis: an experimental study

Aziz Sümer¹, Ediz Altinli², Serkan Senger², Neþet Köksal², Ender Onur³, Ersan Eroðlu², Pembegül Güneþ^4
1Department Of General Surgery, Yüzüncü Yýl Univesity, Medical Faculty,
²Department Of General Surgery, Haydarpaþa Numune Training And Research Hospital
³Department Of General Surgery, Fatih Sultan Mehmet Training And Research Hospital
⁴Department Of Pathology, Haydarpaþa Numune Training And Research Hospital

BACKGROUND
In the current study, we aimed to investigate the influences of pentoxifylline, which increases the flexibility, deformability and viscosity of the erythrocytes while reducing the aggregation abilities of the platelets, and vinpocetine, which has neuroprotective and antioxidant effects, on healing of colonic anastomoses.
METHODS
We used 30 Albino Wistar rats. Subjects were divided into three groups of 10 rats each. Colonic ischemia was established in all the groups. Following colonic transection, anastomosis was performed. Group A received intraperitoneal saline, whereas Group B and Group C received pentoxifylline and vinpocetine, respectively. The subjects were sacrificed on the postoperative 5th day by ether anesthesia, and their colonic bursting pressures were measured. The anastomotic area was excised for hydroxyproline assay and histopathologic examination.
RESULTS
According to intergroup comparisons, colonic bursting pressure was found to be higher in the treatment groups than in the control group; however, the difference was not statistically significant. Intergroup comparisons regarding tissue hydroxyproline levels showed statistically significant differences between Groups A and B, Groups A and C and Groups B and C.
CONCLUSION
Similar to pentoxifylline, vinpocetine was also shown to have a beneficial effect over ischemic colon anastomoses.

Keywords: Colon anastomoses, ischemia; pentoxifylline; vinpocetine.

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ATIF KOPYALA