Ulus Travma Acil Cerrahi Derg. 2019; 25(4): 338-342 | DOI: 10.14744/tjtes.2019.38265

Yanýk yarasý tedavisinde Ankaferd Blood Stoper ile gümüþ sülfadiazinin karþýlaþtýrýlmasý: Deneysel çalýþma

Serden Ay¹, Yaþar Ünlü^2
1KTO Karatay Üniversitesi Týp Fakültesi, Genel Cerrahi Anabilim Dalý, Konya
²Saðlýk Bilimler Üniversitesi, Konya Eðitim ve Araþtýrma Hastanesi, Patoloji Kliniði, Konya

AMAÇ: Bu deneysel çalýþma yanýk yaralarýnda Ankaferd Blood Stoper ve gümüþ sülfadiazinin (SSD) etkinliðini karþýlaþtýrmak üzere dizayn edilmiþtir.
GEREÇ VE YÖNTEM: Çalýþma için Wistar albino cinsi 21 sýçan kullanýldý. Yanýk oluþturmak için 3x3 cm çapýnda yuvarlak özel dizayn edilmiþ pirinç prob kullanýldý. Yanýk oluþturulduktan sonra, sýçanlar üç gruba ayrýldý. Ankaferd Blood Stoper (Grup ABS) grup 1’de, Gümüþ sülfadiazin (Grup SSD) grup 2’de, izotonik emdirilmiþ spançlarda (Grup kontrol) grup 3’de kullanýldý. Ýyiliþme dönemi klinik ve histoplatolojik olarak takip edildi. Yara ölçümleri yapýldý, %50 ve %80 re-epitelizasyona ulaþtýðý günler her sýçan için belirlendi.
BULGULAR: Ortalama %50 re-epitelizasyon zamaný sýrasýyla ABS grubu için 10.8 gün, SSD grubu için 13.8 gün ve kontrol grubu için 16.8 gündü (p<0.001). Yine ortalama %80 re-epitelizasyon zamaný sýrasýyla ABS grubu için 16.4 gün, SSD grubu için 19.7 gün ve kontrol grubu için 25.2 gündü (p<0.001). Ortalama enflamatuvar skora göre, ABS grubunda anlamlý bir fark mevcuttu (p<0.05).
TARTIÞMA: Çalýþmamýz ABS’nin yanýk tedavisinde, SSD’ye oranla daha iyi sonuçlarý olduðunu göstermiþtir.

Anahtar Kelimeler: Ankaferd Blood Stoper, deneysel çalýþma, gümüþ sülfadiazin; yanýk.

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Comparison of Ankaferd Blood Stopper and silver sulfadiazine use in burn wounds: An experimental study

Serden Ay¹, Yaþar Ünlü^2
1Department of General Surgery, KTO Karatay University Faculty of Medicine, Konya-Turkey
²Department of Pathology, Health Sciences University Konya Training and Research Hospital, Konya-Turkey

BACKGROUND: The present study was designed to compare the effectiveness of topical silver sulfadiazine (SSD) and Ankaferd Blood Stopper® (ABS) usage in experimental partial-thickness burns in rats.
METHODS: Twenty-one male Wistar albino rats weighing 250–290 (range: 270±19) g were used in the present study. A round brass probe that was specifically designed (3×3 cm diameter) was used to induce the burns in rats. After the presence of partial-thickness burns was confirmed, the rats were divided into three groups: Group 1 (ABS group) Ankaferd Blood Stopper® pad, Group 2 (SSD group) silver sulfadiazine (Silverdin®), and Group 3 (Control group) 1% isotonic saline solution-impregnated pad. The healing period was followed up clinically and histopathologically. The day on which 50% and 80% of re-epithelization at first were detected for each rat was also recorded.
RESULTS: The mean times of 50% and 80% of re-epithelization at first were 10.8 days, 13.8 days, and 16.8 days in Groups 1, 2, and 3, respectively (p<0.001), and 16.4 days, 19.7 days, and 25.2 days, respectively (p<0.001). The mean inflammatory scores were also found to be better in the ABS group than in other groups (p<0.05).
CONCLUSION: Our study showed that ABS has better results for the healing of the burn wound than SSD in experimental partial-thickness burns in rats.

Keywords: Ankaferd Blood Stopper, burn, experimental study; silver sulfadiazine.

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ATIF KOPYALA