THE CLINICAL AND HISTOPATHOLOGICAL EVALUATION OF EFFECTS OF MAGNESIUM SULPHATE IN EXPERIMENTAL MEDULLA SPINALIS TRAUMA

It is known that secondary injury following spinal trauma develops as a result of a series of biochemical reactions. Several pharmachological agents have been used to break this reaction chain. Magnesium sulphate which acts as a N-methyl-D-aspartate receptor antagonist in the brain was used in this study. At present magnesium sulphate is being used in the treatment of eclampsia and tetanus. In this study, usage of magnesium sulphate resulted in 20% histopathological and 26% clinical improvement of the neurological deterioration which develops as a result of weight drop technic trauma of medulla spinalis and consequent neuronal injury in the rabbits.

DENEYSEL MEDULLA SPÝNALÝS TRAVMASINDA MAGNEZYUM SÜLFATIN KLÝNÝK VE HÝSTOPATOLOJÝK ETKÝLERÝNÝN ÝNCELENMESÝ

Spinal travmalarda sekonder hasarýn bir dizi biyokimyasal reaksiyon sonucu oluþtuðu bilinmektedir. Yapýlan çeþitli çalýþmalarda bu reaksiyon zincirini durdurmaya yönelik birçok farmakolojik ajan denenmiþtir. Bu çalýþmada beyinde N-metil-D-aspartat reseptör antagonisti olarak etki yapan magnezyum sülfat kullanýldý. Magnezyum sülfat klinikte eklampsi ve tetanusda kullanýlan bir ilaçtýr. Tavþanlarda aðýrlýk düþürme yöntemiyle oluþturulan medulla spinalis travmasýndan sonra oluþan nöronal doku hasarý ve bunun sonucu olarak geliþen nörolojik bozukluðunda magnezyum sülfat ile histopatolojik %20, klinik %26 düzelme saðlanmýþtýr.