Effect of intra-abdominal boric acid in the experimental adhesion model

BACKGROUND: The continuous advancement in medical and surgical techniques has led to a rise in the frequency of abdominal operations, subsequently increasing the incidence of intra-abdominal adhesions. Over 90% of laparotomies result in postoperative intra-abdominal adhesions. This study investigates the effect of a 5% boric acid solution on the development of intra-abdominal adhesions in rats, using an adhesion model.
METHODS: This study was conducted with two groups: a control group, in which the adhesion model was applied without any treatment, and a boric acid group, which was treated with a 5% boric acid solution. Each group comprised 16 rats. On the 14th postoperative day, the rats were sacrificed, re-explored, and the developed adhesions were evaluated both macroscopically and microscopically. The data from macroscopic and microscopic scoring were analyzed using the Mann-Whitney U test in the IBM Statistical Package for the Social Sciences (SPSS) Statistics 24 program. A p-value of less than 0.05 was considered statistically significant. This research was supported by the Manisa Celal Bayar University Scientific Research Projects Commission.
RESULTS: A statistically significant difference was observed between the boric acid-treated group and the control group, with the boric acid group showing a significant decrease in adhesion development both macroscopically and microscopically (p<0.05).
CONCLUSION: In the future, boron could play a significant role in reducing and preventing intra-abdominal adhesions after surgery. This investigation could pave the way for further research into the mechanism by which boric acid prevents the development of intra-abdominal adhesions. Moreover, it is imperative to explore the potential side effects of intra-abdominal boron application at the optimum concentration of the solution.

Deneysel adeyon modelinde, entraabdominal borik asidin etkisi

AMAÇ: Bu çalýþmada; batýn cerrahilerinin giderek daha fazla sayýda yapýlmasýyla sýklýkla karþýlaþýlan ve ciddi mortalite ile morbidite sebebi olan intraabdominal adezyonlarýn azaltýlabilmesi için; adezyon modeli oluþturulmuþ ratlarda, %5 borik asit solüsyonu uygulamasýnýn batýn içi adezyon geliþimine etkisini araþtýrmak amaçlanmýþtýr. Borik asidin daha önce kanýtlanmýþ olan antiinflamatuvar, antioksidan ve antifibrotik etkileri ile intraabdominal adezyon geliþimini azaltacaðý düþünülmüþtür.
GEREÇ VE YÖNTEM: Çalýþma her biri 16 adet rat içeren 2 grupta (adezyon modeli oluþturulmuþ kontrol grubu ve %5’lik borik asit solüsyonu uygulanmýþ deney grubu) yapýldý. Operasyon sonrasý 14. günde ratlar sakrifiye edilip tekrar eksplore edildi ve geliþen adezyonlar makroskopik ve mikroskopik olarak deðerlendirildi. Makroskopik ve mikroskobik skorlamalar sonucunda elde edilen veriler IBM SPSS Statistics 24 programýnda Mann-Whitney U testi ile deðerlendirildi. Ýstatistiksel anlamlýlýk düzeyi “p<0.05” olarak belirlendi.
BULGULAR: Ýstatistiksel veriler incelendiðinde borik asit uygulanan grupta adezyon geliþiminde makroskopik ve mikroskopik olarak anlamlý bir azalma olduðu görüldü (p<0.05).
SONUÇ: Bu çalýþmanýn sonucunda; deneysel adezyon modelinde intraabdominal %5’ lik borik asit solüsyonu uygulamasýnýn, postoperatif intraabdominal adezyonlarý azaltmada anlamlý etkiye sahip olabileceði gösterilmiþtir. Bu etkinin borik asidin antiinflamatuvar, antioksidan ve antifibrotik etkilerinden kaynaklandýðý öngörülmektedir. Bu çalýþma, borik asidin intraabdominal adezyonlarý azaltma mekanizmasýnýn ve ideal dozun araþtýrýlmasý için öncü olacaktýr.