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The effects of Sildenafil in liver and kidney injury in a rat model of severe scald burn: A biochemical and histopathological study [Ulus Travma Acil Cerrahi Derg]
Ulus Travma Acil Cerrahi Derg. 2014; 20(5): 319-327 | DOI: 10.5505/tjtes.2014.39586

The effects of Sildenafil in liver and kidney injury in a rat model of severe scald burn: A biochemical and histopathological study

Ali Kağan Gökakın1, Mustafa Atabey1, Koksal Deveci2, Enver Sancakdar2, Mehmet Tuzcu3, Cevdet Duger4, Omer Topcu1
1Cumhuriyet University School Of Medicine, Department Of General Surgery, Sivas/turkey
2Cumhuriyet University School Of Medicine, Department Of Biochemistry, Sivas/turkey
3Cumhuriyet University Faculties Of Veterinary, Department Of Pathology, Sivas/turkey
4Cumhuriyet University School Of Medicine, Department Of Anesthesiology, Sivas/turkey

Severe burn induces systemic inflammation and reactive oxygen species that leads to lipid peroxidation which may play a role in remote organs injury. Sildenafil is a selective and potent inhibitor of cyclic guanosine monophosphate specific phosphodiesterase-5. Sildenafil reduces oxidative stress and inflammation in distant organs. The aim of present study was to evaluate the effects of different dosages of sildenafil in remote organs injury. A total of 32 rats were randomly divided into four equal groups. The groups were designated as follows: Sham, Control, 10, and T20 mg/kg sildenafil treatment groups. Levels of malondialdehyde (MDA), vascular endothelial growth factor (VEGF), VEGF receptor (Flt-1), activities of glutathione peroxidase (Gpx), levels of total antioxidative capacity (TAC), and total oxidant status (TOS) were measured in both tissues and serum, a semi-quantitative scoring system was used for the evaluation of histopathological findings. Sildenafil increased levels of Gpx, and Flt-1, and decreased MDA and VEGF levels in tissues. Sildenafil also increased serum levels of TAC and Flt-1 and decreased TOS, OSI, and VEGF. Sildenafil decreased inflammation scores in remote organs in histopathological evaluation. Sildenafil has protective effects in severe burn-related remote organ injuries by decreasing oxidative stress and inflammation.

Keywords: scald burn, remote organ injury, Sildenafil

Corresponding Author: Ali Kağan Gökakın, Türkiye
Manuscript Language: English
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