Ulus Travma Acil Cerrahi Derg. 2022; 28(11): 1634-1640 | DOI: 10.14744/tjtes.2021.94799

Relationship between admission neutrophil/lymphocyte, thrombocyte/lymphocyte, and monocyte/lymphocyte ratios and 1-year mortality in geriatric hip fractures: Triple comparison

Sezgin Bahadýr Tekin¹, Bahri Bozgeyik², Ahmet Mert^3
1Department of Orthopedics and Traumatology, Gaziantep University Faculty of Medicine, Gaziantep-Türkiye
²Department of Orthopedics and Traumatology, Kadirli State Hospital, Osmaniye-Türkiye
³Department of Orthopedics and Traumatology, Niðde Ömer Halisdemir University Faculty of Medicine, Niðde-Türkiye

BACKGROUND: Elderly patients with hip fractures have a high post-operative 1-year mortality rate. The aim of this study was to investigate the relationship of the neutrophil/lymphocyte ratio (NLR), thrombocyte/lymphocyte ratio (TLR), and monocyte/lymphocyte ratio (MLR) with mortality.
METHODS: The data of 350 patients who suffered femoral intertrochanteric fractures between January 2015 and January 2020 were examined, and the demographic data of 124 patients who met the study criteria were evaluated. During the 1-year follow-up, 92 patients (74%) who continued their lives and 32 patients (25%) who died were divided into two groups: Group 1 (survivors) and Group 2 (non-survivors). NLR, TLO, MLO, presence of comorbidities, age, sex, American Society of Anesthesiologists Physical Status Classification, length of hospital stay, fracture type, and fracture pattern values were statistically compared between the two groups.
RESULTS: NLR, TLR, and MLR are the laboratory parameters assessed within the scope of the study. Preoperatively, the mean NLR was 6.59 (1.61–26.29), mean TLR was 197.94 (86–516), and mean MLR was 0.73 (0.19–15.68). In this study, a significant relationship was found between NLR, TLR, and MLR values and the occurrence of post-operative 1-year mortality (p=0.01). In addition, the result was significant in the correlation between these parameters. Cutoff values were found to be 7.53 for NLR, 192 for TLR, and 0.54 for MLR in receiver operator characteristic curve analysis (p<0.01).
CONCLUSION: NLR, TLR, and PLR are significant predictors of 1-year mortality in patients aged over 60 years with hip fractures.

Keywords: Fracture, hip, lymphocyte; mortality; neutrophil; platelet.

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Geriatrik kalça kýrýklarýnda giriþ nötrofil-lenfosit, trombosit-lenfosit, monosit-lenfosit oranlarý ile bir yýllýk mortalite arasýndaki iliþki: Üçlü karþýlaþtýrma

Sezgin Bahadýr Tekin¹, Bahri Bozgeyik², Ahmet Mert^3
1Gaziantep Üniversitesi Týp Fakültesi, Ortopedi ve Travmatoloji Anabilim Dalý, Gaziantep
²Kadirli Devlet Hastanesi, Ortopedi ve Travmatoloji Kliniði, Osmaniye
³Niðde Ömer Halisdemir Üniversitesi Týp Fakültesi, Ortopedi ve Travmatoloji Anabilim Dalý, Niðde

AMAÇ: Kalça kýrýðý olan yaþlý hastalarda ameliyat sonrasý bir yýllýk mortalite oraný yüksektir. Bu çalýþmanýn amacý nötrofil lenfosit oraný (NLR), trombosit lenfosit oraný (TLR) ve monosit lenfosit oraný (MLR) ile mortalite arasýndaki iliþkiyi araþtýrmaktýr.
GEREÇ VE YÖNTEM: Ocak 2015–Ocak 2020 tarihleri arasýnda femoral intertrokanterik kýrýk nedeniyle baþvuran 350 hastanýn verileri incelendi ve çalýþma kriterlerini karþýlayan 124 hastanýn demografik verileri deðerlendirildi. Bir yýllýk takipte hayatýna devam eden 92 hasta (%74) ile ölen 32 (%26) hasta, grup 1 ve grup 2 (%25) olarak ayrýldý. NLR, TLR, MLR ve yandaþ hastalýklar, yaþ, cinsiyet, ASA, hastanede kalýþ süresi, kýrýk tipi ve kýrýk paterni deðerleri bu iki grup arasýnda istatistiksel olarak karþýlaþtýrýldý.
BULGULAR: Çalýþma kapsamýnda deðerlendirilen laboratuvar parametreleri olan biyokimyasal parametrelerin ortalamasý þöyle idi: NLR 6.59 (1.61–26.29), TLR 197.94 (86–516) ve MLR 0.73 (0.19–15.68). Bu çalýþmada NLR, TLR, MLR deðerleri ile ameliyat sonrasý bir yýllýk mortalite oluþumu arasýnda istatistiksel olarak anlamlý bir iliþki bulundu (p=0.01) Ayrýca bu parametreler arasýndaki korelasyon iliþkisinde sonuç anlamlýydý. ROC (Alýcý operatör karakteristik eðrisi) analizinde kestirim deðerleri NLR için 7.53, TLR için 192 ve MLR için 0.54 olarak bulundu (p<0.01).
TARTIÞMA: NLR, TLR, PLR deðerleri 60 yaþ üstü kalça kýrýðý olan hastalarda bir yýllýk mortalite göstermede anlamlýdýr.

Anahtar Kelimeler: Kalça, kýrýk, lenfosit; mortalite; notrofil; platelet.

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