Thymoquinone Attenuates Trauma Induced Spinal Cord Damage in an Animal Model

�st�n, Nilg�n; Aras, Mustafa; Ozgur, Tumay; Bayraktar, Hamdullah Suphi; Sefil, Fatih; Ozden, Raif; Yagiz, Abdullah Erman

Volume : 20 Issue : 5 Year : 2024

30/4Forthcoming Issue Archive Covers Most Accessed Articles

ICMJE COI Form

Quick Search

Turkish Journal of Trauma and Emergency Surgery Thymoquinone Attenuates Trauma Induced Spinal Cord Damage in an Animal Model [Ulus Travma Acil Cerrahi Derg]

Ulus Travma Acil Cerrahi Derg. 2014; 20(5): 328-332

Thymoquinone Attenuates Trauma Induced Spinal Cord Damage in an Animal Model

Nilg�n �st�n¹, Mustafa Aras², Tumay Ozgur³, Hamdullah Suphi Bayraktar⁴, Fatih Sefil⁵, Raif Ozden⁶, Abdullah Erman Yagiz¹
¹Mustafa Kemal University, Faculty Of Medicine, Department Of Physical Medicine And Rehabilitation, Hatay, Turkey
²Mustafa Kemal University, Faculty Of Medicine, Department Of Neurosurgery, Hatay, Turkey
³Mustafa Kemal University, Faculty Of Medicine, Department Of Pathology, Hatay, Turkey
⁴Mustafa Kemal University, Faculty Of Veterinary, Department Of Clinical Sciences, Hatay, Turkey
⁵Mustafa Kemal University, Faculty Of Medicine, Department Of Physiology, Hatay, Turkey
⁶Mustafa Kemal University, Faculty Of Medicine, Department Of Orthopaedics And Traumatology, Hatay, Turkey

Background: Spinal cord injury (SCI) is one of the most devastating conditions, leading to neurological impairment and disabilities. The aim of the study was to investigate the potential neuroprotective effect of thymoquinone (TQ) histopathologically in an experimental model of traumatic spinal cord injury (SCI). Methods: Twenty-four male Wistar albino rats were randomly divided into 4 groups: control group; SCI group; SCI-induced and 10 mg/kg/day TQ administered group; SCI-induced and 30 mg/kg/day TQ administered group. TQ was given as intraperitoneal for 3 days prior to injury and 4 days following injury. Spinal cord segment between T8 and T10 were taken for histopathologic examination. Hemorrhage, spongiosis and liquefactive necrosis were analyzed semiquantatively for histopathological changes. Results: Administration of TQ at dose of 10 mg/kg did not cause any significant change on histological features of neuronal degeneration as compared to the SCI group (p=0.269); but, 30 mg/kg TQ significantly decreased the histological features of spinal cord damage below that of SCI group (p=0.011). Conclusions: Data from this study suggest that TQ supplementation attenuates trauma induced spinal cord damage. Thus, TQ needs to be taken into consideration, for it may have a neuroprotective effect in trauma induced spinal cord damage.

Keywords: Experimental spinal cord injury, thymoquinone, histologic examination

Timokinon Deneysel Spinal Kord Yaralanmal� Ratlarda Spinal Kord Hasar�n� Azalt�r

Nilg�n �st�n¹, Mustafa Aras², Tumay Ozgur³, Hamdullah Suphi Bayraktar⁴, Fatih Sefil⁵, Raif Ozden⁶, Abdullah Erman Yagiz¹
¹Mustafa Kemal �niversitesi, T�p Fak�ltesi, Fiziksel T�p Ve Rehabilitasyon Ad, Hatay, T�rkiye
²Mustafa Kemal �niversitesi, T�p Fak�ltesi, Beyin Cerrahisi Ad, Hatay, T�rkiye
³Mustafa Kemal �niversitesi, T�p Fak�ltesi, Patoloji Ad, Hatay, T�rkiye
⁴Mustafa Kemal �niversitesi, Veterinerlik Fak�ltesi, Klinik Bilimler Ad, Hatay, T�rkiye
⁵Mustafa Kemal �niversitesi, T�p Fak�ltesi, Fizyoloji Ad, Hatay, T�rkiye
⁶Mustafa Kemal �niversitesi, T�p Fak�ltesi, Ortopedi Ve Travmatoloji Ad, Hatay, T�rkiye

Giri�: Spinal kord yaralanmas� (SKY) n�rolojik bozukluk ve �z�rl�l��e yol a�an en y�k�c� hastal�k durumlar�ndan biridir. Bu �al��man�n amac� deneysel SKY�l� ratlarda timokinonun (TQ) n�roprotektif etkilerinin histopatolojik olarak ara�t�r�lmas�d�r. Materyal ve Metodlar: 24 adet erkek Wistar albino rat 4 gruba ayr�ld�: kontrol grubu; SKY grubu; SKY ve 10 mg/kg/g�n TQ verilen grup; SKY ve 30 mg/kg/g�n TQ verilen grup. TQ intraperitoneal g�nde tek doz yaralanmadan 3 g�n �nce ve yaralanmay� takiben 4 g�n olarak verildi. T8-T10 spinal segmentleri histopatolojik inceleme i�in al�nd�. Segmentler histopatolojik olarak hemoraji, spongioz ve likefaksiyon nekrozu a��s�ndan semikantitatif olarak analiz edildi. Bulgular: 10 mg/kg/g�n TQ verilen SKY grubun spinal kord segmentlerinin histopatoljik incelemesinde anlaml� n�ronal iyile�me saptanmazken (p=0.269), 30 mg/kg/g�n TQ verilen SKY grubunda anlaml� d�zeyde n�ronal iyile�me saptand� (p=0.011). Sonu�lar: Bu �al��madan elde edilen sonu�lar TQ takviyesinin travmaya ba�l� spinal kord hasar�n� azaltt��n� g�stermektedir. Bu nedenle TQ travmatik SKY'da, n�roprotektif etkileri olabilece�i i�in, dikkate al�nmal�d�r.

Anahtar Kelimeler: Deneysel spinal kord yaralanmas�, Timokinon, histolojik inceleme

Nilg�n �st�n, Mustafa Aras, Tumay Ozgur, Hamdullah Suphi Bayraktar, Fatih Sefil, Raif Ozden, Abdullah Erman Yagiz. Thymoquinone Attenuates Trauma Induced Spinal Cord Damage in an Animal Model. Ulus Travma Acil Cerrahi Derg. 2014; 20(5): 328-332

Corresponding Author: Nilg�n �st�n, T�rkiye
Manuscript Language: English

TOOLS Full Text PDF Print Download citation RIS EndNote BibTex Medlars Procite Reference Manager Share with email Share Send email to author Similar articles PubMed Google Scholar