p-ISSN: 1306-696x | e-ISSN: 1307-7945
Cilt : 11 Sayı : 3 Yıl : 2024

Hızlı Arama




SCImago Journal & Country Rank
Turkish Journal of Trauma and Emergency Surgery Karıniçi hipertansiyon modelinde gelişen bakteriyel translokasyon üzerine selektif bağırsak dekontaminasyon ve mekanik bağırsak temizliğinin etkileri [Ulus Travma Acil Cerrahi Derg]
Ulus Travma Acil Cerrahi Derg. 2005; 11(3): 201-205

Karıniçi hipertansiyon modelinde gelişen bakteriyel translokasyon üzerine selektif bağırsak dekontaminasyon ve mekanik bağırsak temizliğinin etkileri

Doğan Gönüllü1, Ahmet Ceylan2, Okan Demiray1, Meltem Erpek Üzümcü3, Ferda Nihat Köksoy1, Osman Yücel1
1Taksim Training and Research Hospital, 2. Clinics of Surgery, İstanbul, Turkey
2Söğüt State Hospital, Bilecik, Turkey
3Taksim Training and Research Hospital, Laboratory of Clinical Microbiology, İstanbul, Turkey


The effect of selective bowel decontamination and mechanical bowel preparation on bacterial translocation due to intraabdominal hypertension

Doğan Gönüllü1, Ahmet Ceylan2, Okan Demiray1, Meltem Erpek Üzümcü3, Ferda Nihat Köksoy1, Osman Yücel1
1Taksim Training and Research Hospital, 2. Clinics of Surgery, İstanbul, Turkey
2Söğüt State Hospital, Bilecik, Turkey
3Taksim Training and Research Hospital, Laboratory of Clinical Microbiology, İstanbul, Turkey

BACKGROUND: The objective of our study is to evaluate the preventive effects of selective digestive decontamination (SDD) and mechanical bowel preparation in rats with experimentally induced bacterial translocation. METHODS: Fourty adult male Sprague Dowley rats weighing 250-300 g. were divided equally into four groups as Group 1 (sham [control]), Group 2 (experimentally induced IAH at 19 mmHg), Group 3 ( SDD group) and Group 4 (SDD and mechanical bowel preparation with 19 mmHg intraabdominal pressure). Group 3 and 4 were treated at 12 hours intervals with oral gentamycine 5 mg/kg and IM sefotaxime 100mg/kg Mechanical bowel preparation was performed by oral administration of sodium phosphate. After 24 hours all rats were sacrified; mesenteric lymph nodes, spleen and liver biopsy specimens were harvested aseptically. Specimens were diluted and cultured in McConkey medium and the colony-forming units (CFU/gr ) were calculated. RESULTS: In Kruskal Wallis tests there were no significant differences between Group 1 and 3 or 4, and also Group 3 and 4 (p>0.05, p=0.872 respectively), while differences between Group 1 and 2, and also Group 3 and 4 were statistically significant (p<0.001) with respect to CFU/g estimates. CONCLUSION: These data indicate that selective intestinal decontamination and mechanical bowel preparation prevent bacterial translocation due to intraabdominal hypertension.


Doğan Gönüllü, Ahmet Ceylan, Okan Demiray, Meltem Erpek Üzümcü, Ferda Nihat Köksoy, Osman Yücel. The effect of selective bowel decontamination and mechanical bowel preparation on bacterial translocation due to intraabdominal hypertension. Ulus Travma Acil Cerrahi Derg. 2005; 11(3): 201-205
Makale Dili: Türkçe